Fliiiight can work with any spoke pattern with between 14 and 64 spokes.
Fliiiight uses spoke detection to gather the high resolution speed data required for Virtual Inertia to work. That means you need visible spokes. It’s not compatible with disc wheels or HED tri-spokes, and if you're using an aero jacket you’ll need to remove it.
See also: Is Fliiiight compatible with bladed spokes?